We performed coimmunoprecipitation experiments to determine which protein is the target of SARS\CoV\2 ORF9b

We performed coimmunoprecipitation experiments to determine which protein is the target of SARS\CoV\2 ORF9b. endosome RNA\sensing pathway of TLR3\TRIF signaling and the adaptor protein of the cytosolic DNA\sensing pathway of O4I2 cGASCSTING signaling, respectively. A mechanistic analysis revealed that this SARS\CoV\2 ORF9b protein interacted with RIG\I, MDA\5, MAVS, TRIF, STING, and TBK1 and impeded the … Continue reading We performed coimmunoprecipitation experiments to determine which protein is the target of SARS\CoV\2 ORF9b